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KMID : 0352720220460040543
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Journal of Ginseng Research
2022 Volume.46 No. 4 p.543 ~ p.549
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Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial
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Yang Yi
Wang Hong
Zhang Ming
Shi Mengxue
Yang Cailing
Ni Qiang
Wang Qi
Li Jing
Wang Xuemei
Zhang Chen
Li Zhi
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Abstract
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Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism.
Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test.
Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group.
Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.
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KEYWORD
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Physical fatigue, Korean Red Ginseng, Blood lactic acid, Creatine phosphokinase
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